MRONJ adversely affects the quality of life, producing significant morbidity. Strategies for management of patients with, or at risk for, MRONJ were set forth in the American Association of Oral and Maxillofacial Surgeons (AAOMS) updated Position Paper on Bisphosphonate-Related Osteonecrosis of the Jaws and approved by the Board of Trustees in 2009.1 The Position Paper was developed by a Special Committee appointed by the Board and composed of clinicians with extensive experience in caring for these patients and basic science researchers. The knowledge base and experience in addressing MRONJ has expanded, necessitating modifications and refinements to the previous Position Paper. This Special Committee met in September 2013 to appraise the current literature and revise the guidelines as indicated to reflect current knowledge in this field. This update contains revisions to diagnosis, staging, and management strategies, and highlights current research status. AAOMS considers it vitally important that this information be disseminated to other relevant health care professionals and organizations.